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1

A new type of synthetic peptide library for identifying ligand-binding activity

Lam, Kit S., Salmon, Sydney E., Hersh, Evan M., Hruby, Victor J., Kazmierski, Wieslaw M., Knapp, Richard J.

Journal:

Year:

1991

File:

PDF, 477 KB

1991

2

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Suoming Zhang, Charles Z. Ding, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Liang Liu, Wei Bu, Wieslaw M. Kazmierski, Lois L. Wright, Gary K. Smith, Rich

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 668 KB

english, 2010

3

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties

Xianfeng Li, Suoming Zhang, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Yasheen Zhou, Jacob J. Plattner, Stephen J. Baker, Wei Bu, Liang Liu, Wieslaw M. Kazmierski, Maosheng Duan, Richard M. Grimes, L

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.21 MB

english, 2011

4

DNA Encoded Library Technology-based discovery, lead optimization and prodrug strategy toward structurally-unique indoleamine 2,3-dioxygenase (IDO1) inhibitors.

Kazmierski, Wieslaw M., XIA, Bing, Miller, John, De La Rosa, Martha, Favre, David, Dunham, Richard, Washio, Yoshiaki, Zhu, Zhengrong, Wang, Feng, Mebrahtu, Makda, Deng, Honfeng, Basilla, Jonathan, Wan

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 460 KB

english, 2020

5

Synthesis and Structural Studies of SP and RP Diastereomers of Deoxyxylothymidyl-3′-O-acetylthymidyl (3′,5′)-O-(2-Cyanoethyl)phosphorothioate in Solution and in the Solid State

Marek J. Potrzebowski, Xian-Bin Yang, Konrad Misiura, Wieslaw R. Majzner, Michal W. Wieczorek, Slawomir Kaźmierski, Sebastian Olejniczak, Wojciech J. Stec

Journal:

European Journal of Organic Chemistry

Year:

2001

Language:

english

File:

PDF, 563 KB

english, 2001

6

Structural characteristics of two highly selective opioid peptides

Richard J. Knapp, Henry I. Yamamura, Wieslaw Kazmierski, Victor J. Hruby

Journal:

Year:

1989

Language:

english

File:

PDF, 527 KB

english, 1989

7

A New Experimental Method to Determine the Mutual Orientation of Helices in Coiled-Coil Proteins: Structural Information about the Dimeric Interface of cJun, cFos, GCN4, and gp41

Dr. Wieslaw M. Kazmierski, Dr. John McDermed, Dr. Ann Aulabaugh

Journal:

Chemistry - A European Journal

Year:

1996

Language:

english

File:

PDF, 1002 KB

english, 1996

8

ChemInform Abstract: Novel and Efficient Synthesis of Spirocyclic Morpholinones as Precursors of Ψ[CH2O] Dipeptide Isosteres.

Paul C. Fritch, Wieslaw M. Kazmierski

Journal:

Year:

1999

File:

PDF, 31 KB

1999

9

ChemInform Abstract: Cyclic Aromatic Amino Acids with Constrained χ1 and χ2 Dihedral Angles

Dirk Tourwe, Koen Iterbeke, Wieslaw M. Kazmierski, Geza Toth

Journal:

Year:

2000

File:

PDF, 29 KB

2000

10

ChemInform Abstract: Novel Inhibitors of HIV Protease: Design, Synthesis and Biological Evaluation of Picomolar Inhibitors Containing Cyclic P1/P2 Scaffolds.

Andrew Spaltenstein, Merrick R. Almond, William J. Bock, Darryl G. Cleary, Eric S. Furfine, Richard J. Hazen, Wieslaw M. Kazmierski, Francesco G. Salituro, Roger D. Tung, Lois L. Wright

Journal:

Year:

2000

File:

PDF, 29 KB

2000

11

ChemInform Abstract: A Convenient Synthesis of the Orthogonally-Protected Benzodiazepine-2,5-dione Scaffold.

Wieslaw M. Kazmierski, John D. McDermed

Journal:

Year:

2000

File:

PDF, 32 KB

2000

12

ChemInform Abstract: Synthesis and Structural Studies of SP and RP Diastereomers of Deoxyxylothymidyl-3′-O-acetylthymidyl (3′,5′)-O-(2-Cyanoethyl)phosphorothioate in Solution and in the Solid State.

Marek J. Potrzebowski, Xian-Bin Yang, Konrad Misiura, Wieslaw R. Majzner, Michal W. Wieczorek, Slawomir Kazmierski, Sebastian Olejniczak, Wojciech J. Stec

Journal:

Year:

2002

File:

PDF, 28 KB

2002

13

ChemInform Abstract: Nucleophilic N1→N3 Rearrangement of 5′-O-Trityl-O2,3-cycloanhydrothymidine.

Xian-Bin Yang, Konrad Misiura, Wojciech J. Stec, Marek J. Potrzebowski, Slawomir Kazmierski, Michal Wieczorek, Wieslaw R. Majzner, Grzegorz D. Bujacz

Journal:

Year:

2002

File:

PDF, 34 KB

2002

14

ChemInform Abstract: Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin.

Paola Zarantonello, Colin P. Leslie, Rafael Ferritto, Wieslaw M. Kazmierski

Journal:

Year:

2002

File:

PDF, 32 KB

2002

15

Novel Spirocyclic Pyrrolidones as P2/P1 Mimetics in Potent Inhibitors of HIV-1 Protease.

Wieslaw M. Kazmierski, Eric Furfine, Andrew Spaltenstein, Lois L. Wright

Journal:

Year:

2003

File:

PDF, 138 KB

2003

16

Recent Progress in Discovery of Small-Molecule CCR5 Chemokine Receptor Ligands as HIV-1 Inhibitors

Wieslaw Kazmierski, Neil Bifulco, Hanbiao Yang, Larry Boone, Felix DeAnda, Chris Watson, Terry Kenakin

Journal:

Year:

2003

File:

PDF, 56 KB

2003

17

Novel Prodrug Approach to Amprenavir-Based HIV-1 Protease Inhibitors via O→N Acyloxy Migration of P1 Moiety.

Wieslaw M. Kazmierski, Patricia Bevans, Eric Furfine, Andrew Spaltenstein, Hanbiao Yang

Journal:

Year:

2003

File:

PDF, 111 KB

2003

18

Discovery of Potent Pyrrolidone-Based HIV-1 Protease Inhibitors with Enhanced Drug-Like Properties.

Wieslaw M. Kazmierski, Webb Andrews, Eric Furfine, Andrew Spaltenstein, Lois Wright

Journal:

Year:

2005

File:

PDF, 12 KB

2005

19

ChemInform Abstract: Discovery of a Novel Series of Cyclic Urea as Potent CCR5 Antagonists.

Maosheng Duan, Wieslaw M. Kazmierski, Matt Tallant, Jung Ho Jun, Mark Edelstein, Rob Ferris, Dan Todd, Pat Wheelan, Zhiping Xiong

Journal:

Year:

2012

File:

PDF, 22 KB

2012

20

Metal chelating amino acids in the design of peptides and proteins. Synthesis of Nα-Fmoc/But protected amino acids incorporating aminodiacetic acid moiety.

Wieslaw M. Kazmierski

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 285 KB

english, 1993

21

Synthesis of the carbonic acid benzotriazol-1-yl-ester-(2-biotinylamino)-9h-fluoren-9-ylmethyl ester: A convenient transient-biotinylation reagent for use in affinity chromatography

Wieslaw M. Kazmierski, John McDermed

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 272 KB

english, 1995

22

Discovery of potent pyrrolidone-based HIV-1 protease inhibitors with enhanced drug-like properties

Wieslaw M. Kazmierski, Webb Andrews, Eric Furfine, Andrew Spaltenstein, Lois Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 301 KB

english, 2004

23

New, potent P1/P2-morpholinone-based HIV-protease inhibitors

Wieslaw M. Kazmierski, Eric Furfine, Andrew Spaltenstein, Lois L. Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 141 KB

english, 2006

24

4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents

Maosheng Duan, Christopher Aquino, George F. Dorsey Jr., Robert Ferris, Wieslaw M. Kazmierski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 568 KB

english, 2009

25

Potent inhibitors of the HIV-1 protease incorporating cyclic urea P1–P2 scaffold

Wieslaw M. Kazmierski, Eric Furfine, Yolanda Gray-Nunez, Andrew Spaltenstein, Lois Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

26

[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists: derivatizations at the N-terminal of the piperidine ring

Maosheng Duan, Christopher Aquino, Robert Ferris, Wieslaw M. Kazmierski, Terry Kenakin, Cecilia Koble, Pat Wheelan, Chris Watson, Michael Youngman

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 1.67 MB

english, 2009

27

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates

Xianfeng Li, Yong-Kang Zhang, Yang Liu, Charles Z. Ding, Yasheen Zhou, Qun Li, Jacob J. Plattner, Stephen J. Baker, Suoming Zhang, Wieslaw M. Kazmierski, Lois L. Wright, Gary K. Smith, Richard M. Grim

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.13 MB

english, 2010

28

Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (I): Optimization of the amine portion

Maosheng Duan, Jennifer Peckham, Mark Edelstein, Robert Ferris, Wieslaw M. Kazmierski, Andrew Spaltenstein, Pat Wheelan, Zhiping Xiong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 380 KB

english, 2010

29

Discovery of N-benzyl-N′-(4-pipyridinyl)urea CCR5 antagonists as anti-HIV-1 agents (II): Modification of the acyl portion

Maosheng Duan, Jennifer Peckham, Mark Edelstein, Robert Ferris, Wieslaw M. Kazmierski, Andrew Spaltenstein, Pat Wheelan, Zhiping Xiong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 255 KB

english, 2010

30

Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

Rena Nishizawa, Toshihiko Nishiyama, Katsuya Hisaichi, Chiaki Minamoto, Naoki Matsunaga, Yoshikazu Takaoka, Hisao Nakai, Stephen Jenkinson, Wieslaw M. Kazmierski, Hideaki Tada, Kenji Sagawa, Shiro Shi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 433 KB

english, 2011

31

Synthesis and evaluation of 2-phenyl-1,4-butanediamine-based CCR5 antagonists for the treatment of HIV-1

Matthew D. Tallant, Maosheng Duan, George A. Freeman, Robert G. Ferris, Mark P. Edelstein, Wieslaw M. Kazmierski, Pat J. Wheelan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.66 MB

english, 2011

32

A new approach to receptor ligand design: synthesis and conformation of a new class of potent and highly selective μ opioid antagonists utilizing tetrahydroisoouinoline carroxylic acid

Wieslaw Kazmierski, Victor J. Hruby

Journal:

Year:

1988

Language:

english

File:

PDF, 1014 KB

english, 1988

33

Asymmetric synthesis of topographically constrained amino acids: synthesis of the optically pure isomers of α,β-dimethyl-phenylalanine and α,β-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

Wieslaw M. Kazmierski, Victor J. Hruby

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 234 KB

english, 1991

34

Novel inhibitors of HIV protease: design, synthesis and biological evaluation of picomolar inhibitors containing cyclic P1/P2 scaffolds

Andrew Spaltenstein, Merrick R Almond, William J Bock, Darryl G Cleary, Eric S Furfine, Richard J Hazen, Wieslaw M Kazmierski, Francesco G Salituro, Roger D Tung, Lois L Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 152 KB

english, 2000

35

A solid-phase approach to analogues of the antibiotic mureidomycin

Andrea Bozzoli, Wieslaw Kazmierski, Gordon Kennedy, Alessandra Pasquarello, Angelo Pecunioso

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 225 KB

english, 2000

36

Total Synthesis and Semi-Synthetic Approaches to Analogues of Antibacterial Natural Product Althiomycin

Paola Zarantonello, Colin P Leslie, Rafael Ferritto, Wieslaw M Kazmierski

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

37

The chemical synthesis of large random peptide libraries and their use for the discovery of ligands for macromolecular acceptors

Kit S. Lam, Victor J. Hruby, Michal Lebl, Richard J. Knapp, Wieslaw M. Kazmierski, Evan M. Hersh, Sydney E. Salmon

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 446 KB

english, 1993

38

Novel spirocyclic pyrrolidones as P2/P1 mimetics in potent inhibitors of HIV-1 protease

Wieslaw M. Kazmierski, Eric Furfine, Andrew Spaltenstein, Lois L. Wright

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 114 KB

english, 2002

39

Novel prodrug approach to amprenavir-based HIV-1 protease inhibitors via O→N acyloxy migration of P1 moiety

Wieslaw M Kazmierski, Patricia Bevans, Eric Furfine, Andrew Spaltenstein, Hanbiao Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 191 KB

english, 2003

40

Recent progress in discovery of small-molecule CCR5 chemokine receptor ligands as HIV-1 inhibitors

Wieslaw Kazmierski, Neil Bifulco, Hanbiao Yang, Larry Boone, Felix DeAnda, Chris Watson, Terry Kenakin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 481 KB

english, 2003

41

Corrigendum to “Recent Progress in Discovery of Small–Molecule CCR5 Chemokine Receptor Ligands as HIV-1 Inhibitors” [Bioorg. Med. Chem. 2003, 11, 2663–2676]

Wieslaw Kazmierski, Neil Bifulco, Hanbiao Yang, Larry Boone, Felix DeAnda, Chris Watson, Terry Kenakin

Journal:

Bioorganic & Medicinal Chemistry

Year:

2003

Language:

english

File:

PDF, 79 KB

english, 2003

42

Peptide, Peptidomimetic and Small-molecule Drug Discovery Targeting HIV-1 Host-cell Attachment and Entry through gp120, gp41, CCR5 and CXCR4

Wieslaw M. Kazmierski, Terry P. Kenakin, Kristjan S. Gudmundsson

Journal:

Chemical Biology & Drug Design

Year:

2006

Language:

english

File:

PDF, 555 KB

english, 2006

43

Recent advances in the design and synthesis of small-molecule mimetic drugs

Wieslaw M. Kazmierski

Journal:

Trends in Biotechnology

Year:

1994

Language:

english

File:

PDF, 360 KB

english, 1994

44

Small-molecule CCR5 Ligands that may Spare the CCR5 Function: Opportunity for New Antiviral Discovery?

Wieslaw Kazmierski, Vanessa Muniz-Medina, Susan Danehower, Stacey Jones, Terry Kenakin

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 270 KB

english, 2009

45

4,4-Disubstituted Cyclohexylamine based CCR5 Chemokine Receptor Antagonists as Anti-HIV-1 agents

Maosheng Duan, Wieslaw Kazmierski, Christopher Aquino, Rob Ferris, Terry Kenakin, Chris Watson, Pat Wheelan

Journal:

Antiviral Research

Year:

2009

Language:

english

File:

PDF, 164 KB

english, 2009

46

Discovery of novel pyridyl carboxamides as potent CCR5 antagonists and optimization of their pharmacokinetic profile in rats

Maosheng Duan, Wieslaw M. Kazmierski, Pek Y. Chong, Felix DeAnda, Mark Edelstein, Rob Ferris, Jennifer Peckham, Pat Wheelan, Zhiping Xiong, Huichang Zhang, Rena Nishizawa, Yoshikazu Takaoka

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 447 KB

english, 2011

47

Discovery of a novel series of cyclic urea as potent CCR5 antagonists

Maosheng Duan, Wieslaw M. Kazmierski, Matt Tallant, Jung Ho Jun, Mark Edelstein, Rob Ferris, Dan Todd, Pat Wheelan, Zhiping Xiong

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 587 KB

english, 2011

48

Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease

Maosheng Duan, Wieslaw Kazmierski, Renae Crosby, Margaret Gartland, Jinjing Ji, Matt Tallant, Amy Wang, Robert Hamatake, Lois Wright, Min Wu, Yong-Kang Zhang, Charles Z. Ding, Xianfeng Li, Yang Liu, S

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 783 KB

english, 2012

49

Proton n.m.r. investigation of conformational influence of penicillamine residues on the disulfide ring system of opioid receptor selective Somatostatin derivatives

ELIZABETH E. SUGG, DIRK TOURWE, WIESLAW KAZMIERSKI, VICTOR J. HRUBY, GEORGES VAN BINST

Journal:

Chemical Biology & Drug Design

Year:

1988

Language:

english

File:

PDF, 472 KB

english, 1988

50

Cholecystokinin analogues with high affinity and selectivity for brain membrane receptors

VICTOR J. HRUBY, SUNAN FANG, RICHARD KNAPP, WIESLAW KAZMIERSKI, GEORGE K. LUI, HENRY I. YAMAMURA

Journal:

Chemical Biology & Drug Design

Year:

1990

Language:

english

File:

PDF, 600 KB

english, 1990

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